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european medicines agency


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common pathogenetic principle of CrF and SBS, Dantzer et al. and Bower and Lamkin suggested a cause-effect chain that ema- nates from a cellular and humoral immune response as a result of stressors such as chemotherapeutic agents or ionizing radia- tion (Fig. 2.1). In terms of safety, in 2011, the European Medicines Agency (EMA) recommended vigilance with the use of this drug, as modafinil was associated with adverse reactions including hypersensitivity and serious skin reactions (e.g.

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