Children with a temperature above 38.5�C meeting any high-risk feature (see above) should have a CBC, blood culture, reticulocyte.count, and, if clinically indicated, a urine culture sent and received a parenteral antibiotic with activity against Streptococcus pneumoniae and Haemophilus influen- zae, such as ceftriaxone 50 mg/kg IV or EM, as soon as possible.
Febrile children with undifferentiated or nonbenign neutropenia should have blood cultures sent and broad-spectrum antibiotics initiated.
Obtain blood and wound cultures prior to giving antibiotics when pos- sible, as the majority of patients will have positive blood cultures to confirm a streptococcal pathogen.
Initial laboratory studies for patients with suspected sepsis often include a CBC with differential and platelet count, lactic acid level, serum electro- lytes, liver function panel, renal function panel, arterial blood gas analysis, blood cultures, urinalysis, and urine culture.
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