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A trend toward increased risk of barotrauma (RR 1.19; 95 % CI 0.83-1.72) and unfavorable hemodynamics (RR 1.16; 95 % CI 0.97-1.39) was also observed [15].
Furthermore, an increased barotrauma associated with the use of HFOV cannot be excluded.
blockade), refractory barotrauma (persistent pneumothorax or increasing subcuta- neous emphysema despite double thoracic drainage), or refractory acidosis (pH of
Moreover, recent meta-analyses proved that the application of HFOV was associated with a trend toward an increased risk of barotrauma and unfa- vorable hemodynamics [15].
According to the most recent data, HFOV does not offer any real advantage com- pared to current protective lung ventilation, but it is associated with a major need of sedative and neuromuscular blocker drugs, unstable hemodynamics, and lung barotrauma.
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