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بیوراکتور
Second, it can be grown rapidly to high cell densities on relatively simple media in both small culture vessels and largescale bioreactors.
In largescale bioreactors, depleted nutrients and accumulation of toxic cell waste can limit the viability and density of cells as they respond to stress by inducing cell death, also known as apoptosis.
One method to im prove cell growth and viability under culture conditions in bioreactors is to prevent the tumor suppressor protein p53, which is a transcription factor, from activating the cell death response pathway.
Cell death (apoptosis), stimulated by the transcription factor p53, can lead to decreased yields of recombinant mammalian cells grown under stressful conditions in large bioreactors.
Engineered cells not only showed delayed cell death, but also achieved higher cell densities in bioreactors.
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