1
عمومی::
کموکین
Instead of delivering exogenous macrophages, a number of studies have exerted control over the accumulation of endogenous macro- phages via pharmacologic targeting of chemokines and receptors that regulate tissue infiltration.
Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor CC- chemokine receptor (CCR)-2 also regulate recruitment of monocytes, which differentiate into macrophages as they infiltrate damaged tissue [25].
Similarly, recovery from spinal cord injury in mice improved following treatment with a blocking anti- body against another important monocyte chemokine receptor, CCR5, concomitant with reduced total macrophage numbers but increased proportion of those that expressed CD206, an M2 marker [72].
Interest- ingly, although wounds in diabetic mice exhibit prolonged inflamma- tion associated with persistent elevations in MCP-1 and CCR2 [73], the very early stage of diabetic wound healing has been associated with re- duced levels of this chemokine system as well as reduced levels of CD68 + cells [31].
Locati, The chemokine system in diverse forms of macrophage activation and polarization, Trends Immunol. 25 (12) (2004) 677-686.
واژگان شبکه مترجمین ایران