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زیست شناسی::
دیودیناز
Type II deiodinase removes an iodine atom from the outer ring of the precursor hormone (T4) to convert it into the more active hormone T3.
Type III deiodinase removes an iodine atom from the inner ring of T3 to convert it into an inactive compound (T2) that will eventually be metabolized to tyrosine (Becker et al. 1997).
Tadpoles that are genetically modified to overexpress type III deiodinase in their target tissues never complete metamorphosis (Huang et al. 1999); therefore the regulation of metamorphosis involves tissue specific regulation of the form of the hormone that binds most effectively to its receptor.
The tissues that respond earliest to the thyroid hormones are those that express high levels of deiodinase II and thus can convert Tj directly into T3 (Cai and Brown 2004).
For instance, the limb rudiments, which have high levels of both deiodinase II and TRa, can convert Xi into T3 and use it immediately through the TRa receptor.
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