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دیهیدروفولات
The dihydrofolate reductase-methotrexate system falls into this category.
Dihydrofolate reductase catalyzes the reduction of dihydrofolate to tetrahydrofolate, which is required for the production of purines.
Sensitivity to methotrexate can be overcome if the cell produces excess dihydrofolate reductase, and as the methotrexate concen tration is increased over time, the dihydrofolate reductase gene in cultured cells is amplified.
It is not unusual for methotrexateresistant cells to have hundreds of dihydrofolate reductase genes.
The standard dihydrofolate
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