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دی پپتید
After infusion, the dipeptide N(2)-L-alanyl-L-glutamine is quickly divided into ala- nine and glutamine.
For this reason, only glutamine-containing dipeptides (alanyl- or glycyl-glutamine) and not free glutamine are added to enteral or parenteral nutrition solutions.
, patients randomized to glutamine received 0.35 per kg of ideal body weight per day of the amino acid supplementation (provided as intravenous 0.50 g/kg/day of the dipeptide alanyl-glutamine plus 42.5 g/day of enteral alanyl-glutamine and glycine-glutamine dipeptides, which provide 30 g of
According to pharmaceutical industry recommendations, glutamine dipeptide should not be administered to patients with severe liver dysfunction, renal insuffi- ciency (creatinine clearance <25 mL/min), or severe metabolic acidosis.
Parenteral dipeptide solutions are widely used in European countries, while their use in the United States is currently not approved by the Food and Drug Administration.
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