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شیمی::
فلوروراسیل
A very significant example is that of capecitabine, a multistep, orally active prodrug of 5-fluorouracil, an anticancer agent.
Capecitabine thus affords an impressive gain in therapeutic benefit compared to 5-fluorouracil due to its oral bioavailability and a relatively selective activation in and delivery to tumors.
Classification of Prodrugs Based on Where They are Converted into Active Drugs Class Conversion Site Sub Type Tissue Location of Conversion Examples I Intracellular I A Therapeutic target Zidovudine Tissues or cells 5-fluorouracil I B Metabolic tissues (liver, lungs) Captopril Cyclophosphamide II Extracellular II A Gastrointestinal fluid Sulfasalazine Loperamide oxide II B Systemic circulation Fosphenytoin Bambuterol
Plasma enzyme-catalyzed hydrolysis of the N-acyl derivatives makes N-acylation of amide or imide fruitful in some cases, such as N-acetyl- 5-fluorouracil and N-ethoxy carbonyl-2-fluorouracil.
Improved physi- cochemical properties and easy bioconversion of N-acyl derivative of 5-fluorouracil enhances the oral and rectal absorption of the parent drug.
واژگان شبکه مترجمین ایران
2
عمومی::
فلورویوراسیل
* fluorouracil (5FU)
* Cyclophosphamide - Methotrexate - Fluorouracil (5FU) (also known as CMF)
* Fluorouracil (5FU) - Epirubicin - Cyclophosphamide (also known as FEC)
Common chemotherapy drugs for bowel cancer are fluorouracil, capecitabine and oxaliplatin.
* folinic acid (leucovorin or calcium folinate), fluorouracil and oxaliplatin (FOLFOX)
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