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عمومی::
ماکروفاژ
Keywords: Macrophages Regenerative medicine Inflammation
In particular, macrophages have emerged as a primary target because of their critical roles in regulating multiple phases of tis- sue repair through their unique ability to rapidly shift phenotypes.
Herein, we review macrophage-based thera- pies, focusing on the translational potential for cell delivery of ex vivo-activated macrophages and delivery of molecules and biomaterials to modulate accumulation and phenotype of endogenous macrophages.
We also re- view current obstacles to progress in translating basic findings to therapeutic applications, including the need for improved understanding of context-dependent macrophage functions and the myriad factors that regulate mac- rophage phenotype; potential species-specific differences (e.g. humans versus mice); quality control issues; and the lack of standardized procedures and nomenclature for characterizing macrophages.
Looking forward, the in- herent plasticity of macrophages represents a daunting challenge for harnessing these cells in regenerative med- icine therapies but also great opportunity for improving patient outcomes in a variety of pathological conditions.
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