داستان آبیدیک

macrophage


فارسی

1 عمومی:: كلان‌ خوار، (ط‌ب‌) یاخته‌ بیگانه‌ خوار درشت‌

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2 عمومی:: ماکروفاژ

Keywords: Macrophages Regenerative medicine Inflammation In particular, macrophages have emerged as a primary target because of their critical roles in regulating multiple phases of tis- sue repair through their unique ability to rapidly shift phenotypes. Herein, we review macrophage-based thera- pies, focusing on the translational potential for cell delivery of ex vivo-activated macrophages and delivery of molecules and biomaterials to modulate accumulation and phenotype of endogenous macrophages. We also re- view current obstacles to progress in translating basic findings to therapeutic applications, including the need for improved understanding of context-dependent macrophage functions and the myriad factors that regulate mac- rophage phenotype; potential species-specific differences (e.g. humans versus mice); quality control issues; and the lack of standardized procedures and nomenclature for characterizing macrophages. Looking forward, the in- herent plasticity of macrophages represents a daunting challenge for harnessing these cells in regenerative med- icine therapies but also great opportunity for improving patient outcomes in a variety of pathological conditions.

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