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[129] showed that long term (90 days) effects could be achieved by just 10-30 days of controlled re- lease of dexamethasone, an anti-inflammatory glucocorticoid, from synthetic scaffolds encapsulating pancreatic islet cells for cell transplan- tation therapy of diabetes.
Zheng et al. generated a similar protective population by polarizing iso- lated macrophages with IL-4 and IL-13 and then adoptively transferring the stimulated cells into mice with pancreatic and renal injuries (Zheng et al.
Indeed, pancreatic beta cell renewal following bile duct injury is tightly regulated by M(IL-4) macrophages expressing TGF-b1 (Xiao et al.
Transfused macrophages amelio- rate pancreatic and renal injury in murine diabetes mellitus.
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