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شیمی::
فیزیکی-شیمیایی
Not all are going to become real drug candidates due to their inherent physicochemical properties.
Even so, the modern discovery technologies, such as HTS and combinatorial chemistry, can produce novel lead structures with high pharmacological potency, but the physicochemical and biopharmaceuti- cal aspects of the initial leads have frequently been neglected.
A significant variation is seen in order to improve or eliminate drawbacks related to physicochemical properties which determine the pharmacokinetic behavior, and pharmaceutical and biological performance of already existing drugs.
To overcome the undesirable physicochemical, biological, and organoleptic properties of some marketed drugs, the development of new chemical compounds with satisfactory efficacy and safety has to be made.
Traditionally, the prodrug approach was aimed at improving the physicochemical properties of drugs via covalently attaching the drug moiety to a nontoxic chemical species, the promoiety.
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