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زیست شناسی::
پره سنیلین
A large number of mutations spread throughout the structures of proteins presenilin 1 and 2 which are linked to Alzheimer's disease [7, 24].
The protein presenilin 1 is an integral mem- brane protein.
Membrane topology of Alzheimer's disease-related presenilin 1 was explained in detail in the Ref
Presenilin 1 and 2, which are highly homologous to each other, were reported to be mainly localized in the membranes of intracellular compartments such as the endoplasmic reticulum.
A convincing membrane topol- ogy model for both of these presenilins 1 and 2 was proposed.
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