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عمومی::
رمیفنتانیل
Remifentanil.
In patients undergo- ing craniotomy for supratentorial space-occupying lesions, 1 痢/kg of remifentanil caused no change in ICP.105 In a second investigation in patients undergoing craniotomies, approximately 0.35 痢/kg/min of remifentanil resulted in CBF values comparable to those observed with moderately deep anesthesia with either isoflurane-N2O or fentanyl- N2O,106 and CO2 responsiveness was preserved.
Greater doses of remifentanil may have more substantial effects.
MCAfv decreased by 30% in response to 5 痢/kg, followed by 3 痢/kg/min of remifentanil at a constant MAP in patients being anesthetized for bypass surgery.69 However, a lower dose of 2 痢/kg, followed by an infusion of 3 痢/kg/min, did not affect MCAfV.
Quantitatively, the effects of remifentanil appear to be similar to those of sufentanil.
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