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پیری
The second line of defense, discussed below, is a population of hepatic progenitor cells that are normally quiescent but that are activated when the injury is severe and adult hepatocytes cannot regenerate well due to senescence, alcohol abuse, or disease.
The first is simply how long an organism lives; the second concerns the physiological deterioration, or senescence, that characterizes old age.
Both aging and senescence have genetic and environmental components, and so far there is no unified theory of aging that puts them all together.
There is no single hypothesis that explains aging and senescence.
As cells become senescent, they have been seen to secrete paracrine factors that mimic inflammatory responses and suppress organ function.
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