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They are nontoxic and thought to be one of the most suitable promoieties to reduce ulcerogenic tendency.
Polysaccharide Used as Promoieties Conjugation with Drug Advantage 1 Chondrotin sulfate Ibuprofen, ketoprofen and naproxen Synergistic anti-inflammatory effect and delayed release of drug 2 Cyclodextrin Mefenamic acid Reduction in ulcerogenic potential 3 Chitosan glucosamine Metronidazole Colon-targeted drug delivery 4 Dextran Flurbiprofen and suprofen Improved analgesic and antipyretic effect with low ulcerogenic potential 5 Dextran Metaxalone Improved pharmacokinetics and longer half-life 6 Dextran conjugates Valproic acid Reduction in hepatotoxicity and ulcerogenicity 7 Dextran conjugates Acyclovir Targeting of antiviral to liver
Phytophenols Used as Promoieties Conjugation with Drug Advantage 1 Menthol, thymol, eugenol Ibuprofen Synergistic analgesic action and decreased gastrointestinal toxicity 2 Guiacol, eugenol, thymol, vanillin, umbelliferone Diclofenac Reduced ulcerogenic side effects 3 Guiacol Mefenamic acid Synergistic anti-inflammatory activity and less toxicity
Amine Used as Promoieties Conjugation with Drug Advantage 1 Propylamine, diethylamine, cyclohexyl amine, 2-amino ethyl amine, 2-hydroxyl ethyl amine Ketoprofen Reduced gastrointestinal side effects, improved analgesic activity 2 Ethylenediamine and benzathine conjugate Ibuprofen Reduced gastrointestinal side effects, improved analgesic activity 3 Heterocyclic amide Ibuprofen Improved analgesic activity, lower ulcerogenic activity 4 Amide derivatives Diclofenac Lower ulcerogenic activity 5 Cysteamine Ibuprofen and indometacin Antioxidant activity and lower ulcerogenic activity 6 Glycine amides Ketoprofen Lower ulcerogenic activity
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