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شیمی::
دسترسی زیستی (زیستفراهمی)
However, these computa- tional methods, along with the techniques used for developing a drug candidate, can provide good in vitro drug activity but cannot be extrapolated to good in vivo drug activity unless a drug candidate has good bioavailability and a desirable duration of action.
Such prodrugs suffer from nonspecific activa- tion at sites other than the active site, resulting in related toxicities and low bioavailability.
prodrugs to designing prodrugs for specific targeting of enzymes and transporters, thus increasing bioavailability and reducing toxicity, and therefore achieving a better therapeutic profile of drug candidate (Karaman, 2014).
The three major phases involved in the drug receptor interaction or biological bioavailability of drug include:
Foremost among these is a need to improve oral bioavailability, be it by improving the oral absorption of the drug and/or by decreasing its presystemic hepatic metabolism.
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