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عمومی::
بیومتریال، بیومتریال
a Biomaterials and Regenerative Medicine Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, United States
Herein, we review macrophage-based thera- pies, focusing on the translational potential for cell delivery of ex vivo-activated macrophages and delivery of molecules and biomaterials to modulate accumulation and phenotype of endogenous macrophages.
Design of biomaterials to manipulate macrophage phenotype 78
Strategies under investigation to manip- ulate macrophage behavior in regenerative medicine can be grossly divided into four categories: those that administer exogenously activat- ed macrophages, those that aim to increase or decrease macrophage numbers, those that employ local or systemic delivery of bioactive fac- tors to alter the phenotype of the macrophages that accumulate follow- ing injury, and those that modulate macrophage phenotype through the design of immunomodulatory biomaterial implants (Fig. 2; Table 1).
Patterned biomaterials to increase M2-like polarization،Gallucci is the Chair of the Department of Restorative Dentistry and Biomaterials Sciences and the Head of the Division of Regenerative and Implant Sciences at Harvard School of Dental Medicine, USA.
In collaboration with leading clinics, research institutes and universities, Straumann conducts research, develops and manufactures dental implants, instruments, prosthetics, as well as dental biomaterials for use in tooth replacement and restoration, or to prevent tooth loss.
Engineering and implant manufacturing in Switzerland, with other production sites for biomaterials and CAD/CAM in Europe, the United States and Japan.
From "one fits all" to indication based use of biomaterials - a shift of paradigm in regenerative treatment concepts.
The presentation will provide an overview on the biologic background, surgical considerations and clinical decision tree of using various biomaterials in reconstructive periodontal surgery for intrabony, furcation and recession defects.
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