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In a Finnish study20 in infants with birthweights of less than 1000 g, severe retinopathy of prematurity was seen in only 5-10% (no numbers reported).
In a study of infants with birthweights of less than 1251 g, disease onset began at roughly 30 weeks' postmenstrual age and peaked at 36-38 weeks' post menstrual age, irrespective of gestational age at birth.
In a US national survey,56 infants with a birthweight of less than 1500 g who had a maximum SpO2 greater than 98% in the first 2 postnatal weeks had severe retinopathy in 5·5% of cases, compared with 3·0% in those with a maximum SpO2 of 98% or less (p<0·05).
Gestational age and birthweight
Low gestational age and low birthweight for gestational age are major risk factors for retinopathy of prematurity.18 Both factors are related to the extent of immaturity of retinal neural and vascular development at birth, and therefore the retinal vulnerability to insult.
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