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دکستران
In these, macromolecules, such as polysaccharides, dextrans, cyclo- dextrins, proteins, peptides, and polymers, are used as carriers.
Various polysaccharides, such as cyclodex- trin, dextran, pectin, chitosan, and chondroitin are conjugated with drugs.
Dextran has excellent physicochemical properties and physiological response, and a unique pharmacokinetic profile.
Polysaccharide Used as Promoieties Conjugation with Drug Advantage 1 Chondrotin sulfate Ibuprofen, ketoprofen and naproxen Synergistic anti-inflammatory effect and delayed release of drug 2 Cyclodextrin Mefenamic acid Reduction in ulcerogenic potential 3 Chitosan glucosamine Metronidazole Colon-targeted drug delivery 4 Dextran Flurbiprofen and suprofen Improved analgesic and antipyretic effect with low ulcerogenic potential 5 Dextran Metaxalone Improved pharmacokinetics and longer half-life 6 Dextran conjugates Valproic acid Reduction in hepatotoxicity and ulcerogenicity 7 Dextran conjugates Acyclovir Targeting of antiviral to liver
Dextran is a complex, branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths ranging from 3 to 2000 kDa.
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