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فروتنظیم
At later stages, lipid mediators such as resolvins, anti-inflammatory cytokines and cellular processes such as efferocytosis (the phagocytosis of apoptotic cells) downregulate the M1-like phenotype and induce an M2-like phenotype [40-44].
Inflammasome inhibitors (local) to downregulate M1-like macrophages
IL-17 blocking antibody (local) to downregulate M1-like macrophages
TNF-α blocking antibody (systemic) to downregulate M1-like macrophages
IRF-5 siRNA (systemic) to downregulate M1-like macrophages
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