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فروتنظیم
Global gene profiling indicates that the end result of these pathways is to downregulate (but not totally suppress) the genes involved in the differentiated functions of liver cells while activating those genes
The frog brain also undergoes changes during metamorphosis, and one of its functions is to downregulate metamorphosis once metamorphic climax has been reached.
Downregulation of the insulin signaling pathway has several other functions.
Calorie restriction is another way of downregulating the insulin pathway (Kenyon 2001; Roth et al. 2002; Holzenberger et al. 2003).
It may upregulate mTORCl and downregulate Foxo transcription factors.
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