1
عمومی::
انوکساپارین
Failure to adjust dosages of medications can have disastrous consequences, which is borne out by the example of enoxaparin, which can result in severe bleeding if administration
Enoxaparin, a low-molecular-weight heparin, was found to reduce the risk of DVT by 30% compared with unfractionated heparin in a group of high-risk trauma patients, without a difference in adverse events. ftis trial and subsequent ones have established enoxaparin as preferred VTE prophylaxis for high-risk patients.
In contrast to enoxaparin, only a small amount of unfractionated heparin is metabolized by the kidneys, and it is often used in patients with AKI.
Enoxaparin was approved with fixed dosing, but the advent of an assay for activated factor X along with treatment failures in obese patients led to the interest in weight-based dosing.
Enoxaparin dosed 0.5 mg/kg twice daily based on actual body weight, targeted for anti-factor Xa levels of 0.2 to 0.5 IU/mL has been shown to be an appropriate and safe strategy for obese ICU patients.
واژگان شبکه مترجمین ایران