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اپی لپتوژنیک
monly used anesthetics have some epileptogenic potential,
A concern is that seizure activity may go unrecognized in an anesthetized and paralyzed patient and may result in neuronal injury if substrate demand (CMR) exceeds supply for a prolonged period.204 A second concern is that the epileptogenic effect will persist in the postanesthesia period when seizures may occur in less well-controlled circumstances than those that exist in the surgical unit.
Nonetheless, in patients with pro- cesses that might predispose them to seizures, the use of potentially epileptogenic drugs should be avoided in situ- ations during which reasonable alternatives are available.
Enflurane is potentially epileptogenic in clinical setting.
Of note was the observation that the parox- ysmal activity was not restricted to the ictal focus and that the administration of sevoflurane did not provide any assis- tance in localizing the epileptogenic region of the brain.212 The development of tonic-clonic movements suggestive of seizure activity has also been reported in otherwise healthy patients on emergence from sevoflurane anesthesia.213,214 In all of the reported cases of seizure activity attributable to sevoflurane anesthesia, untoward sequelae have not been documented.
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