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فیبروز
The function of pro-resolving macrophages is to restore homeostasis while minimizing fibrosis via apoptosis of myofibroblasts, suppression of T cell proliferation and a return to balanced MMP/TIMP levels (Murray and Wynn, 2011).
Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly?
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue repair, regeneration, and fibrosis.
Disturbances in macrophage function can lead to aberrant repair, such that uncontrolled production of in- flammatory mediators and growth factors, deficient generation of anti-inflammatory macrophages, or failed communication between macrophages and epithelial cells, endothelial cells, fibroblasts, and stem or tissue progenitor cells all contribute to a state of persistent injury, and this could lead to the development of path- ological fibrosis.
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