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فوسامپرناویر
6.2.2 Fosamprenavir: A Soluble Prodrug Leads to a Better Product
Dan Todd (GlaxoSmithKline Plc, USA) converse Fosamprenavir as a prodrug of amprenavir with improved aqueous solubility.
After screening several potential prodrugs in vitro and in vivo, the phosphate prodrug fosamprenavir was selected because of its high water-solubility, solution and solid- state stability and its rapid conversion to the parent drug on the apical side of epithelium prior to absorption of the parent drug.
The prodrug Fosamprenavir was approved by the FDA in October 2003 for use in combination with other antiretroviral agents for the treatment of HIV infection in adults.
Fosamprenavir is hydrolyzed to the active amprenavir.
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