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عمومی::
چندمرکزی
Their randomized multicenter study had the primary objective of reducing 28-day mortality for hemorrhagic shock trauma patients.
These first encouraging results led to a multicenter phase III trial performed in 2009 in the United States [32].
The largest study was a randomized controlled multicenter phase III trial
, in a large multicenter randomized clinical trial, proved that early application of HFOV in patients with moderate to severe ARDS was asso- ciated with higher mortality rate when compared with a ventilation strategy that used small tidal volumes and high positive end-expiratory pressure (PEEP) levels (with HFOV applied only in the subgroup of patients with severe refractory hypox- emia) [13].
A later meta-analysis confirmed that glutamine supplementation was associ- ated with a significant increase in mortality when included trials were limited to multicenter, randomized trials: 35 % (434 of 1,232 patients) for those receiving glutamine versus 31 % (385 of 1,231 patients) for controls (p = 0.015 for the com- parison).
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