داستان آبیدیک

oxazolidine


فارسی

1 شیمی:: اوکسازولیدین

A chemical strategy developed by medicinal chemists to overcome the problem of biological variety is the development of prodrugs activated by non-enzymatic hydrolysis, for example, imines, Mannich bases, (2-oxo-l, 3-dioxol-4-yl) methyl esters, or oxazolidines. Prodrugs of amines are generally designed by making their amide, N- (acyloxy alkoxy carbonyl) derivatives and oxazolidine derivatives. 4.7.2 Oxazolidines Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydroly- sis in aqueous solution. Oxazolidines are weaker bases (pKa 6 7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.

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