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زیست شناسی::
H. polymorpha
chains of human hemoglobin A were produced from cDNAs in the methylo trophic yeast Hansenula polymorpha.
H. polymorpha produced a truncated version of the human protein interleu kin6 (IL6), whereas A. adeninivorans produced a fulllength version of the protein.
Module and gene Donor Integration 25S rDNA A. adeninivorans 18S rDNA A. adeninivorans 18S rDNA H. polymorpha Replication 2µm ARS S. cerevisiae ARS1 S. cerevisiae HARS H. polymorpha Selection URA3 S. cerevisiae LEU2 S. cerevisiae ALEU2m A. adeninivorans ATRP1m A. adeninivorans HIS4 P. pastoris Expression MOX promoter H. polymorpha AOX1 promoter P. pastoris TEF1 promoter A. adeninivorans GAA promoter A. adeninivorans RPS7 promoter Y. lipolytica Adapted from Gellissen et al.
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