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پیشگروه عاملی
Traditionally, the prodrug approach was aimed at improving the physicochemical properties of drugs via covalently attaching the drug moiety to a nontoxic chemical species, the promoiety.
• Because of altered pH or hypoxia Depending on selected prodrug method (usually bioprecursors) Life cycle management Introducing any kind of promoiety
The evaluation of prodrug is also required to check the nature of promoiety and its interference in physicochemical property and activity as well.
In some cases, such as mutual prodrugs, where both drug and promoiety have activity, synergistic activity may result.
In carrier-linked prodrugs, a drug mole- cule, the usefulness of which is limited by its adverse physicochemical properties, is attached to a carrier group of promoiety to form a new compound, i.e.
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