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زیست شناسی::
استپرتوکیناز
Figure 3.60 Protease (plasmin) sensitivity of streptokinase and some engineered plasminresistant derivatives.
The horizontal arrows indicate plasmin di gestion of streptokinase.
Streptokinase, a 47kilodalton (kDa) protein produced by pathogenic strains of Streptococcus bacteria, is a blood clot-dissolving agent.
Unfortunately, plasmin also rapidly degrades streptokinase, making it necessary for medical personnel to administer streptokinase as a 30 to 90minute infusion so that a sufficient level of intact and active streptoki nase is maintained.
Since it is essential that individuals suffering a heart attack be treated as quickly as possible, a longlived streptokinase could be administered as a single injection before a person is transported to a hospital.
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