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عمومی::
زیرجلدی، زیرجلدی
Subcutaneous Increased vascularization in
subcutaneous implant in mice [98]
Subcutaneous Reduced fibrous capsule
In a study of bio- material vascularization for bone regeneration, the release of the pro- inflammatory cytokine interferon-γ (IFN-γ) from decellularized bone scaffolds caused M1 polarization of seeded human macrophages in vitro, as measured by gene expression and protein secretion of a variety of pro-inflammatory markers, and resulted in increased vascularization in a murine subcutaneous implantation model [98].
This effect extended to the in vivo environment, with pat- terned materials showing increased Arg1 expression and reduced fi- brous encapsulation in a murine subcutaneous implantation model [100].
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