1
زیست شناسی::
گلیکوپروتئین
Mammalian cells, on the other hand, remove some mannose residues from the precursor (trimming) and then sequentially add specific sugars to yield a glycoprotein with an oligo saccharide that terminates in sialic acid.
Figure 3.30 Differential processing of glycoproteins in P. pastoris, humans, and "humanized" P. pastoris.
Initial additions of sugar residues to glycoproteins in the endoplasmic reticulum are similar in human and P. pastoris cells (A).
P. pastoris cells have been engineered to produce enzymes that process glycoproteins in a manner similar to that of human cells.
In "humanized" P. pastoris, a recombinant glycoprotein produced in the endo plasmic reticulum (D) is transported to the Golgi apparatus, where it is further processed to yield a properly sialylated glycoprotein (E).
واژگان شبکه مترجمین ایران