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چربی دوست
• Low lipophilicity
The physicochemical parameters affecting drug action include solubil- ity, lipophilicity, and partition coefficient.
As a result, these agents are more lipophilic and may pass into the mucosa of the stomach.
The lipophilicity is generally the subject of profound alteration of the parent molecule.
By appropriate esterification of the hydroxyl group(s), it is possible to obtain derivatives with desirable lipophilicity as well as in vivo liability; the latter is influenced by electronic and steric factors.
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