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Less well understood is the role of pre-programming of cells prior to the tis- sue repair response, which may include biasing of phenotype via differ- entiation of monocytes and/or epigenetic marking of progenitor cells that is passed down to daughter cells [45-48].
CCR2 siRNA in nanoparticles to reduce monocyte infiltration MCP-1 RNA oligonucleotides to reduce monocyte infiltration
Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor CC- chemokine receptor (CCR)-2 also regulate recruitment of monocytes, which differentiate into macrophages as they infiltrate damaged tissue [25].
In hyper-inflammatory apolipoprotein E-deficient mice, mono- cyte-directed siRNA against CCR2 encapsulated in nanoparticles reduced inflammatory (Ly6Chi) monocytes and improved myocardial infarct healing [70].
In addition, systemic treatment with MCP-1- targeting L-enantiomeric RNA oligonucleotides reduced inflammatory monocyte infiltration and steatohepatitis following chemical- and diet-induced liver injury in mice [71].
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