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زیست شناسی::
پلاسمینوژن
The enzyme tissue plasminogen activator (tPA) is a multidomain serine protease that is medically useful for the dissolution of blood clots.
Streptoki nase forms a complex with plasminogen that results in the conversion of plasminogen to plasmin, the active protease that degrades fibrin in the blood
The 328aminoacid peptide that remains following the digestion by plasmin has approximately 16% of the activity of intact streptokinase in activating plasminogen, and it is slowly degraded by plasmin until no activity remains.
Both single mutants, as well as the double mutant, had the same ability to bind to and activate plasminogen as did the native form of streptokinase.
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