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تلومراز
TELOMERASE AND P53 The transcription factor p53 is one of the most important regulators of cell division.
The enzyme complex that maintains telomere integrity is telomerase, which acts as an antisenescence complex.
Mice and humans with telomerase deficiencies age prematurely (Mitchell et al. 1999).
Overexpressing telomerase or reactivating it in senescent cells extends longevity in mice without increasing cancer (Tomas-Loba et al. 2008; Jaskelioff et al. 2011; Bernardes de Jesus et al. 2012).
Proteins that regulate DNA repair and cell division (such as p53 and telomerase) may be important regulators of aging.
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