2
عمومی::
انقباض عروق، انقباض عروقی، انقباض عروقی
Considerable side effects, with the so-called stroma-free Hb, were mainly related to renal impairment due to vasoconstriction and led to abandon these potential blood substitutes.
It is likely that DCLHb might have worsened outcomes by scavenging nitric oxide (NO) with worsening of hemorrhage and reduction of tissue perfusion due to vasoconstriction.
Nitric oxide, an endothelial-derived relax- ing factor, is a strong heme ligand, and its reduction results in systemic and pulmo- nary vasoconstriction, decrease in blood flow, release of proinflammatory mediators, and loss of platelet inactivation, predisposing conditions for vascular thrombosis and hemorrhage [17, 22] (Table 11.3).
Nitric oxide scavenging causing microvascu- lar vasoconstriction and reduction in functional capillary density is the major side effect for many of the HBOCs (Table 11.3).
Nevertheless, when tested in animal models, vasoconstriction due to NO scavenging and increase in amylase and lipase levels led to project abandonment [35].،The principal defect created by amniotic fluid embolism is a mechanical blockage of a part of the pulmonary circulation accompanied by vasoconstriction of the remaining vessels resulting from release of undefined chemicals such as prosta- glandins, leukotrienes, serotonin, and histamine.
High spontaneous abortion rates may be related to cocaine-induced vasoconstriction, enhanced uterine contraction, and abrupt changes in systemic blood pressure.
Nevertheless, many healthy neonates still have cyanosis at 1 minute owing to peripheral vasoconstriction in response to cold ambient temperatures in the delivery room.
Acidosis and pulmonary vasoconstriction are the most likely causes of persistent cyanosis.
normal newborns the increase in Pao2 to more than 60 mm Hg causes vasoconstriction and functional closure of the duc- tus arteriosus.
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