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عمومی::
ایسکمیک، ایسکمیک
In a phase 2B clinical trial of 125 patients treated for dilated cardiomyop- athy (ischemic heart failure), transendocardial administration of ixmyelocel-T led to a 37% reduction in adverse cardiac events compared with the placebo group over 12 months of follow-up [53].
By contrast, intramyocardial delivery of non-expanded autologous bone marrow mononuclear cells failed to show clinical improvement in a separate study of patients treated for ischemic cardiomyopathy [56], although the two treatments have not been directly compared in the same study.
following ischemic injury [94]
Reduced fibrosis following traumatic or ischemic injury [63,64]
Finally, systemic M-CSF has been reported to increase macro- phage numbers and improve repair following ischemic kidney injury in mice [68] and promoted remyelination following spinal cord injury in،Differentiating between a pressure ulcer and an ischemic ulcer in the lower extremity can be particularly difficult.
The patient's prior medical history included a myocardial infarction, hypertension (treated with medication), type 2 diabetes mellitus, and a questionable history of transient ischemic attack.
ischemic areas.
In addition to prolonged inflam- mation, Hart5 suggests several other factors that may induce chronicity, including recur- rent physical trauma, ischemic reperfusion injury, subclinical bacterial contamination, and foreign bodies.
Exercise caution, for example, in dealing with necrotic ulcers on ischemic limbs, which may have poor perfusion.1,12 Debriding heel ulcers remains controversial because of prob- lems with perfusion and the small amount
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