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عمومی::
فارماکوژنتیک
Define pharmacogenetics and pharmacogenomics.
This has given birth to the field of pharmacogenetics, which seeks to characterize inter-individual drug-response variability at the genetic level (Mancinelli et al, 2000).
Advances in pharmacogenetics have been enabled by high-throughput technology that allows for the screening of tens of thousands of genes rapidly and simultaneously.
Application of pharmacogenetics to pharmacokinetics and pharmacodynamics helps in development of models that may predict an individual's risk to an adverse drug event and therapeutic response (Fernandez-Rozadilla et al, 2013; Meyer et al, 2013).
This chapter will focus on variations in pharmacokinetic components due to pharmacogenetic factors.
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