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[0044] FIG. 5A and FIG. 5B show pharmacokinetics of humanized antibody variants in mouse plasma over time.
FIG. 5B demonstrates that three later developed humanized antibody variants L15H11, L46H11, and L47H65 exhibited pharmacokinetics profiles comparable to the chimeric antibody.
[00336] Five initial humanized antibody variants were tested for pharmacokinetics in normal mice, in comparison with a commercially available antibody Herceptin (Genentech, south San Francisco, CA) and the chimeric Ta1505 antibody.
[00351] A study was conducted to analyze the brain concentration of the humanized variants with improved plasma pharmacokinetics.
[00356] FIG. 6A demonstrates that the humanized antibody variants with good pharmacokinetics (e.g.
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