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زیست شناسی::
فنوتیپ
Until recently, relatively few people exhibited the general human senescent phenotype: gray hair, sagging and wrinkling skin, arthritic joints, osteoporosis (loss of bone calcium), loss of muscle fibers and muscular strength, memory loss, eyesight deterioration, and slowed sexual responsiveness.
"Wear-and-tear" theories of aging are among the oldest hypotheses proposed to account for the human senescent phenotype (Weismann 1891; Medawar 1952).
If the cell is a stem cell or some other rapidly replicating cell, this will reduce the numbers of cells produced, and the lack of stem cells will produce an "aged" phenotype.
The right question may be, "How can evolution select for phenotypes that postpone reproduction or sexual maturity?"
Alternatively, there are other areas of the body, such as the brain, where histone deacetylases can generate an aging phenotype.
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عمومی::
فنوتیپ
NR2F1hi/p27hi/Ki-67lo/p-S6lo phenotype and remained in a dormant single-cell state.
system does not allow monitoring long-term phenotypes in
suppression phenotype caused by C26 treatment, we performed
due to induction of NR2F1 and a dormancy phenotype.
growth arrest phenotype induced by C26 in DTCs.
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