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فنیلافرین
Administration of phenylephrine to patients undergoing cardiopulmonary bypass does not decrease CBF.
In spinal cord-injured patients with relative hypotension, the admin- istration of the a1-agonist midodrine increased perfusion pressure and increased flow velocity in the middle cerebral artery (MCA) and the posterior cerebral artery.26 In healthy patients,27 and in those undergoing surgery in the beach chair position,28 the administration of phenylephrine main- tains or augments MCAfv.
Collectively, these data suggest that norepinephrine and phenylephrine maintain cerebral perfusion.
In anesthe- tized patients,29-31 phenylephrine administration by bolus modestly reduced regional cerebral oxygen saturation (rSO2), measured by near-infrared oximetry.
Ephedrine, although increasing arterial blood pressure to a similar extent as phenylephrine, did not reduce rSO2, presumably because of its ability to maintain cardiac output.
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